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Home / Proteins & Peptide

CTLA4 (Mouse), Fc-Fusion (Human), Avi-Tag, Biotin Labeled

SKU : BHP18200706

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BPS Bioscience

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Mfr.No.	79001
Description	Mouse secreted CTLA4, with C-terminal Avi-Tag fused at the C-terminus with the Fc portion of human IgG1 and biotin labeled, also known as Cytotoxic T-lymphocyte-associated protein 4 and CD152. GenBank Accession No. NM_009843, a.a. 36-161 expressed in a HEK293 cell expression system. The protein is enzymatically biotinylated using AviTag technology. MW = 42 kDa. This protein runs at a higher MW by SDS-PAGE due to glycosylation.
Background	The protein kinase c (PKC)/ Ca2+ response pathway leads to activation of the transcription factor nuclear factor of activator T cells (NFAT). NFAT is regulated by Ca2+ and the Ca2+/calmodulin-dependent serine phosphatase calcineurin. NFAT proteins are phosphorylated and reside in the cytoplasm in resting cells; upon stimulation, they are dephosphorylated by calcineurin, translocate to the nucleus, and induce gene expression.
Immunogen Region	36-161
Tag	Fc fusion protein (IgG1), C-terminal Avi-Tag
Formulation	8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol.
Species	Mouse
Notes	Avoid freeze/thaw cycles.
GenBank	NM_009843
Mw(kda)	42 kDa

Synonyms	Cytotoxic T-lymphocyte-associated protein 4, CD152,
Uniprot	Q6GTR6

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	Stable at least 6 months at -80°C. Protein may be diluted to>= 100 ug/ml in PBS + glycerol and stored at -80°C.

Reference	1. Dilek, N., et al., PLoS ONE. 2013; 8(12): e83139. 2. Leach, D.R., et al., Science. 1996; 271(5256):1734-1736.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200706	79001	50 ug	$478.50		Add to Cart

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