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Home / Proteins & Peptide

CNTF, Human(HEK 293-expressed)

SKU : BHP18500245

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Mfr.No.	IX03071, IX03071-10, IX03071-50
Description	Ciliary neurotrophic factor (CNTF) is a polypeptide initially purified from chick embryo ocular tissue and identified as a trophic factor for embryonic chick ciliary parasympathetic neurons in culture. Subsequent studies have demonstrated that CNTF is a survival factor for additional neuronal cell types including: dorsal root ganglion sensory neurons, sympathetic ganglion neurons, embryonic motor neurons, major pelvic ganglion neurons and hippocampal neurons. CNTF has also been shown to prevent the degeneration of motor axons after axotomy. The gene for human CNTF has been localized to the proximal region of the long arm of chromosome 11. CNTF is highly conserved across species and exhibits cross-species activities. Human and rat CNTF share approximately 83% homology in their protein sequence. CNTF is structurally related to IL-6, IL-11, LIF and OSM. All of these four helix bundle cytokines share gp130 as a signal-transducing subunit in their receptor complexes.
Reconstitution	Reconstituted in ddH2O or PBS at 100 ug/ml.
Formulation	Lyophilized after extensive dialysis against PBS.
Molecular Weight	22~28 kDa, observed by reducing SDS-PAGE.
Source	HEK 293
Host	Human
Accession Number	P26441.1
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Notes	For research use only
Bioactivity	ED50 0.20 ug/ml, measured in a cell proliferation assay using TF-1 cells.

Synonyms	Ciliary Neurotrophic Factor
Sequence	MAFTEHSPLT PHRRDLCSRS IWLARKIRSD LTALTESYVKHQGLNKNINL DSADGMPVAS TDQWSELTEA ERLQENLQAYRTFHVLLARL LEDQQVHFTP TEGDFHQAIH TLLLQVAAFAYQIEELMILL EYKIPRNEAD GMPINVGDGG LFEKKLWGLKVLQELSQWTV RSIHDLRFIS SHQTGIPARG SHYIANNKKM

Purity	95% as analyzed by SDS-PAGE.
Storage	Lyophilized recombinant Human Ciliary Neurotrophic Factor (CNTF) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Human Ciliary Neurotrophic Factor (CNTF) should be stable up to 1 week at 4°C or up to 2 months at -20°C.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500245-1	IX03071-10	10ug	$62		Add to Cart
BHP18500245-2	IX03071-50	50ug	$199		Add to Cart

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