Human chromodomain helicase DNA binding protein 2, or CHD2, (GenBank Accession No. NM_001271) a.a. 260-456(end), with N-terminal GST-tag, MW=49.3 kDa, expressed in an E. coli cell expression system.
Background
The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template.
Immunogen Region
260-456(end)
Tag
N-terminal GST-tag
Formulation
40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Species
Human
Application
Useful for protein binding assays, screening inhibitors, and selectivity profiling.
Notes
Avoid freeze/thaw cycles.
GenBank
NM_001271
Mw(kda)
49.3 kDa
Synonyms
chromodomain helicase DNA binding protein 2
Uniprot
O14647
Shipping Temperature
-80°C (dry ice)
Format
Aqueous buffer solution
Storage
At least 6 months at -80°C.
Reference
1. Woodage, T., et al., Proc Natl Acad Sci USA. 1997 Oct 14;94(21):11472-7. 2. Harada, A., et al., EMBO J. 2012 May 8;31(13):2994-3007.