Human chromodomain protein Y-linked 1 (CDY1), also known as CDY and testis-specific chromodomain protein Y 1, GenBank Accession No. NM_170723, a.a. 2-90, with N-terminal His-tag, MW=11.7 kDa, expressed in an E. coli cell expression system.
host species: E. coli
Host species: E. coli
Background
Chromodomain proteins are components of heterochromatin-like complexes and can act as gene repressors. CDY1 contains a chromodomain and a histone acetyltransferase catalytic domain. CDY1 has histone acetyltransferase activity, with a preference for histone H4. This protein is localized to the nucleus of late spermatids where histone hyperacetylation takes place. Histone hyperacetylation is thought to facilitate the transition in which protamines replace histones as the major DNA-packaging protein.
Immunogen Region
2-90
Tag
N-terminal His-tag
Formulation
40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 300 mM imidazole, 0.04% Tween20, 20% glycerol.
Species
Human
Application
Useful for protein binding assays, screening inhibitors, and selectivity profiling.
Notes
Avoid freeze/thaw cycles.
GenBank
NM_170723
Mw(kda)
11.7 kDa
Synonyms
chromodomain protein Y-linked 1, CDY1, CDY, testis-specific chromodomain protein Y1
Uniprot
Q9Y6F8
Shipping Temperature
-80°C (dry ice)
Format
Aqueous buffer solution
Storage
At least 6 months at -80°C.
Reference
1. Fischle, W., et al., J Biol Chem. 2008 Jul 11;283(28):19626-35. 2. Kleiman, S.E., et al., Fertil Steril. 2011 Jun;95(7):2297-302.