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Home / Proteins & Peptide

CDK7/CyclinH1/MNAT1, His-tags

SKU : BHP18200170

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BPS Bioscience

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Mfr.No.	40098
Description	Complex of recombinant human CDK7, Cyclin H1 and MNAT1, full length, with N-terminal His-tags (CDK7 and MNAT1) and C-terminal His-tag (CyclinH1) , (GenBank Accession Nos. NM_001799, NM_001239, and NM_002431 respectively), co-expressed in Sf9 insect cells via a baculovirus expression system. host species: Sf9 cells Host species: Sf9 cells Specific activity: 21 pmol/min/ug
Background	CDK7 gene is a member of the cyclin-dependent protein kinase family that is important regulators of cell cycle progression (1). CDK7 forms a trimeric complex with cyclin H and MAT1, which functions as a CDK-activating kinase (CAK). CDK7 is an essential component of the transcription factor TFIIH that is involved in transcription initiation and DNA repair. CDK7 is thought to serve as a direct link between the regulation of transcription and the cell cycle (2).
Immunogen Region	full length
Tag	N-terminal His-tag (CDK7 and MNAT1), C-terminal His-tag (CyclinH1)
Formulation	50 mM sodium phosphate pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.2 mM DTT, 25% glycerol
Species	Human
Application	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Notes	Avoid freeze/thaw cycles.
GenBank	NM_001799, NM_001239, NM_002431
Mw(kda)	40 kDa (CDK7), 39 kDa (Cyclin H1), 37 kDa (MNAT1)

Synonyms	Cyclin-Dependent Kinase 7, CAK1, STK1, CDKN7, p39MO15 Cyclin H1: CCNH, CAK, p34, p37 MNATI: MAT1, RNF66
Uniprot	CDK7: P50613; CyclinH1: P51946; MNAT1: P51948

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Purity	>=80%
Storage	At least 6 months at -80°C.

Reference	1. Fisher, R. P.;A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase. Cell 78: 713-724, 1994. 2. Larochelle, S. Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells. Molec. Cell 25: 839-850, 2007.

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200170	40098	10 ug	$423.50		Add to Cart

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