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Home / Proteins & Peptide

CBX1, GST-tag

SKU : BHP18200481

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Mfr.No.	55009
Description	Human chromobox homolog 1 (CBX1), also known as p25beta, M31, HP1-beta, and MOD1, GenBank Accession No. NM_006807, a.a. 2-185(end), with N-terminal GST-tag, MW=48.1 kDa, expressed in an E. coli cell expression system.
Background	Component of heterochromatin. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Recognizes and binds histone H3 tails methylated at Lys9, leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.
Immunogen Region	2-185(end)
Tag	N-terminal GST-tag
Formulation	40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 16 mM glutathione, and 20% glycerol.
Species	Human
Application	Useful for protein binding assays, screening inhibitors, and selectivity profiling.
Notes	Avoid freeze/thaw cycles.
GenBank	NM_006807
Mw(kda)	48.1 kDa

Synonyms	chromobox homolog 1, CBX1, p25beta, M31, HP1-beta, MOD1
Uniprot	P83916

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	1. Furuta, K., et al., Chromosoma. 1997 Jun;106(1) :11-9. 2. Ekblad, C.M., et al., EMBO Rep. 2005 Jul;6(7) :675-80.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200481	55009	100 ug	$506		Add to Cart

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