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Home / Proteins & Peptide

Caspase8, His-tag

SKU : BHP18201755

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BPS Bioscience

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Mfr.No.	80114-2
Description	Human Caspase 8 (CASP8), GenBank Accession No. NM_001228), a.a. 200 - 496 (end), with C-terminal His-tag, MW=34.5 kDa, expressed in an E. coli cell expression system. Procaspase-8 is autocleaved between the prodomain and large protease subunit (p18). The cleavage product, p30, contains both the large (p18) and small (p10 (His-tag)) protease subunits. p30 is further processed to the p18 and p10 subunits, which dimerize to form active enzyme. Specific activity: >= 1145 pmol/min/ug
Background	Caspase-8 is a member of the caspase (cysteine aspartate protease) family of proteins, and has been shown to be an executioner protein of apoptosis. Caspase-8 has been associated with chronic inflammation and neurodegenerative disorders including Alzheimer's, Huntington's, and Parkinson's.
Immunogen Region	200 - 496 (end)
Tag	C-terminal His-tag
Formulation	40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 200 mM imidazole, 3 mM DTT and 20% glycerol.
Species	Human
Application	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Notes	Assayed using BPS's Homogeneous Caspase-8 Assay Kit, Cat. # 80704. 50 mM HEPES, pH 7.2,50 mM NaCl, 10 mM EDTA, 0.1% Chaps,5% glycerol, 10 mM DTT, and 20 uMCaspase 8 substrate. Incubate for 30minutes at room temperature. Fluorescenceintensity is measured at exc380/em505 nm. Avoid freeze/thaw cycles.
GenBank	NM_001228
Mw(kda)	see Description

Synonyms	Caspase-8, CASP8, Caspase 8, FLICE, MACH, Mch5
Uniprot	Q14790

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	1. MacPherson, G., et al., J. Natl.Cancer Inst. 2004 Dec 15;96(24):1866-9. 2. Sun, T., et al., Nat Genet. 2007 May;39(5):605-13. 3. Hoffman, J.C., et al. Mol. Cell. Biol. 2009 Aug; 29(16): 4431-4440.

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SKU	Supplier No.	Size	Your price	Quantity
BHP18201755	80114-2	50 ug	$533.50		Add to Cart

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