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Home / Proteins & Peptide

Caspase6, His-tag

SKU : BHP18201752

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Mfr.No.	80113-1
Description	Human Caspase 6 (CASP6), GenBank Accession No. NM_001226, full length, a.a. 1-293 (end), with C-terminal His-tag, expressed in an E. coli cell expression system. Pro-caspase-6 is activated by autocleavage to yield 20 kDa and 18 kDa proteins (large subunit) and an 11 kDa small subunit (His-tag) that dimerize to form the active enzyme. Specific activity: >= 1720 pmol/min/ug
Background	Caspase-6 is a member of the caspase (cysteine aspartate protease) family of proteins, and has been shown to be an executioner protein of apoptosis. Recent evidence shows that caspase-6 is involved in neurodegenerative diseases, such as Huntington's and Alzheimer's.
Immunogen Region	1-293 (end)
Tag	C-terminal His-tag
Formulation	40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 320 mM imidazole, 0.01% Tween-20, and 20% glycerol.
Species	Human
Application	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Notes	Assayed using BPS's Homogeneous Caspase-6 Assay Kit, Cat. # 80703. 50 mM HEPES, pH 7.2, 50mM NaCl, 10 mM EDTA, 0.1% Chaps, 5%glycerol, 10 mM DTT, and 20 uM Caspase 6substrate. Incubate for 30 minutes at roomtemperature. Fluorescence intensity ismeasured at exc380/em505 nm. Avoid freeze/thaw cycles.
GenBank	NM_001226
Mw(kda)	see Description

Synonyms	Caspase-6, CASP6, Caspase 6, Mch2
Uniprot	P55212

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	1. Halawani, D., et al., J Neurosci. 2010 Apr 28;30(17):6132-42. 2. LeBlanc, A., et al., J Biol Chem. 1999 Aug 13;274(33):23426-36.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18201752	80113-1	10 ug	$313.50		Add to Cart

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