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Home / Proteins & Peptide

Carbonic Anhydrase 9 (CA9), His-tag

SKU : BHP18200580

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Mfr.No.	71101
Description	Human carbonic anhydrase IX (CA IX), also known as CA9, (GenBank Accession No. NM_001216), a.a. 59-414 with C-terminal His-tag, MW = 39.7 kDa, expressed in a baculovirus infected Sf9 cell expression system. Specific activity: >= 30,000 pmol/min/ug
Background	CA IX is a transmembrane protein and the only tumor-associated carbonic anhydrase isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. Expression of the membrane-bound carbonic anhydrase, CA IX, has been reported in hypoxic tumors where its activity is linked to promoting survival of tumor cells and aiding cancer progression. This is thought to occur through the carbonic anhyrase-mediated production of bicarbonate ions, which neutralizes the abnormally acidic pH of the extracellular environment induced during hypoxia. Furthermore, as CA IX is a hypoxia- and HIF-1-inducible enzyme, its expression can be used as a biomarker for hypoxic tumors.
Immunogen Region	59-414
Tag	C-terminal His-tag
Formulation	40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, 266 mM imidazole and 20% glycerol
Species	Human
Application	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Notes	15 mM Trizma hemisulfate, pH 7.6, and 3 mM p-Nitrophenyl acetate (PNPA). Incubate for 30 minutes at room temperature. Absorbance is measured at 410 nM. Avoid freeze/thaw cycles.
GenBank	NM_001216
Mw(kda)	39.7 kDa

Synonyms	Carbonic Anhydrase IX, PMW, RCC-Associated Antigen G250, CAIX, Carbonic Anhydrase 9, Carbonate Dehydratase, CA9
Uniprot	Q16790

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	1. Hilvo, M., et al., J Biol Chem. 2008 Oct 10;283(41):27799-809. 2. Chadwick, A.L., et al., Cell Cycle. 2013 Jul 30;12(16):2534.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200580	71101	100 ug	$555.50		Add to Cart

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