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Home / Proteins & Peptide

BMX, GST-tag

SKU : BHP18200233

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BPS Bioscience

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Mfr.No.	40402
Description	Recombinant full-lengthhuman cytoplasmic tyrosine-proteinkinase BMX (BMX), also known as bonemarrow tyrosine kinase gene inchromosome X protein, epithelial andendothelial tyrosine kinase, ETK, andNTK38 was expressed by baculovirus inSf9 insect cells using an N-terminal GSTtag, a.a. 1-675 (end). The geneaccession number is NM_001721(variant 2). Host cell line: Sf9 cells Specific activity: 43 pmol/min/ug
Background	The BMX gene encodes a non-receptor tyrosine kinase, which may play a role in the growth and differentiation of hematopoietic cells (1). The BMX gene is located on chromosomal band Xp22.2 between the DXS197 and DXS207 loci. Interestingly, chromosome X also contains the closest relative of BMX, the BTK gene, implicated in X-linked agammaglobulinemia. BMX, is found to induce activation of the Stat signaling pathway (2).
Immunogen Region	full length
Tag	N-terminal GST-tag
Formulation	50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25%glycerol
Species	Human
Application	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Notes	Assay was done in Kinase buffer containing 0.2 mM DTT using Poly-(Tyr,Glu) substrate (0.2 mg/ml) and 20 mM ATP. Reaction was done at 30°C for 45 min. Amount of ATP transferred was measured using Kinase-Glo reagent (Promega) Avoid freeze/thaw cycles. Storing diluted enzyme is not recommended. If necessary, use carrier protein (BSA 0.1 - 0.5%).
GenBank	NM_001721
Mw(kda)	110 kDa

Synonyms	ETK, PSCTK2, PSCTK3, bone marrow tyrosine kinase gene in chromosome X protein, epithelial and endothelial tyrosine kinase, NTK38
Uniprot	P51813

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	1. Tamagnone, L. et al. Oncogene. 1994 Dec;9(12):3683-8. 2. Saharinen, P. et al. Blood. 1997 Dec 1;90(11):4341-53

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200233	40402	10 ug	$390.50		Add to Cart

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