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Home / Proteins & Peptide

BMP-2, Human

SKU : BHP18500137

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iXCells Biotechnologies

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Mfr.No.	IX02913, IX02913-1, IX02913-10, IX02913-50
Description	Human Bone Morphogenetic Protein-2 (BMP-2) is a bone-growth regulatory factor and belongs to the transforming growth factor-beta (TGF-beta) superfamily. Human Bone Morphogenetic Protein-2 (BMP-2) is synthesized as large precursor molecule (Met1-Arg396, with a signal peptide from Met1 to Gly23), propeptide (Leu24-Arg282) of which is cleaved by PCSK5 (Proprotein Convertase Subtilisin/Kexin type 5). The active form consists of a dimer of two identical proteins which are linked by a disulfide bond at Cys360. It plays an important role in the development of bone and cartilage, cardiac cell differentiation and epithelial to mesenchymal transition. It is also involved in the hedgehog pathway, TGF-beta signaling pathway, and in cytokine-cytokine receptor interaction. Recombinant human Bone Morphogenetic Protein-2 (rhBMP-2) produced in E. coli is a disulfide-linked homodimer containing two non-glycosylated polypeptide chains of 115 amino acids. A fully biologically active molecule, rhBMP-2 has a molecular mass of 26 kDa analyzed by non-reducing SDS-PAGE and is obtained by proprietary refolding and chromatographic techniques.
Reconstitution	Reconstituted in 20 mM AcOH or 5 mM HCl. The solubility should be at 100 ug/ml.
Formulation	Lyophilized after extensive dialysis against 50 mM acetic acid.
Molecular Weight	26 kDa, observed by non-reducing SDS-PAGE
Source	E. coli
Host	Human
Endotoxin Level	1 EU/ug, determined by LAL method.
Bioactivity	Assay #1: Measured by its ability to induce alkaline phosphatase production by ATDC-5 Cells, The ED50 for this effect is typically 0.07-0.2 ug/mL. Assay #2: Measured by its ability to induce alkaline phosphatase production by C2C12 cells, The ED50 for this effect is typically 0.2-1 ug/mL.

Synonyms	BMP-2, BMP2A, Bone morphogenetic protein 2, BMP-2A, BMP2
Sequence	MQAKHKQRKR LKSSCKRHPL YVDFSDVGWN DWIVAPPGYHAFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACCVPTELSAISM LYLDENEKVV LKNYQDMVVE GCGCR

Purity	95% as analyzed by non-reducing SDS-PAGE and HPLC analyses
Storage	Lyophilized recombinant human Bone Morphogenetic Protein-2 (rhBMP-2) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rhBMP-2 should be stable up to 2 weeks at 4°C or up to 3 months at -20°C.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500137-1	IX02913-1	1mg	$1997		Add to Cart
BHP18500137-2	IX02913-10	10ug	$107		Add to Cart
BHP18500137-3	IX02913-50	50ug	$336		Add to Cart

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