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Home / Proteins & Peptide

BD-3, Mouse

SKU : BHP18500120

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iXCells Biotechnologies

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Mfr.No.	IX02895, IX02895-1, IX02895-20
Description	Beta defensin-3, also known as BD-3 and DEFB-3, is a membrane active cationic peptide that functions in inflammation and innate immune responses and coded by Defb 3 gene on chromosome 8 in mouse. There are at least 30 beta-defensins which are distinguished from alpha-defensins by the connectivity pattern of their three intramolecular disulfide bonds. BD3 is widely expressed among epithelial tissues, notably by keratinocytes and airway epithelial cells. It is upregulated in response to proinflammatory cytokines, microbial and viral infections, and at the edges of skin wounds. BD3 induction in osteoarthritis chondrocytes promotes MMP1 and 13 productions and inhibits TIMP1 and 2 expressions.
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <= -20 °C. Further dilutions should be made in appropriate buffered solutions.
Formulation	Lyophilized from a 0.2 um filtered concentrated solution in 2 x PBS, pH 7.4.
Molecular Weight	Approximately 4.6 kDa, a single non-glycosylated polypeptide chain containing 41 amino acid residues.
Physical Appearance	Sterile Filtered White lyophilized (freeze-dried) powder.
Source	E. coli
Host	Mouse
Endotoxin Level	Less than 1 EU/ug of rMuBD-3 as determined by LAL method.
Bioactivity	Fully biologically active when compared to standard. The ED50 as determined by anti-microbial activity against E.coli. is less than 20 ug/ml, corresponding to a specific activity of 50 IU/mg.

Synonyms	BD-3 Murine; BD 3 Murine
Sequence	KKINNPVSCL RKGGRCWNRC IGNTRQIGSC GVPFLKCCKRK

Purity	95 % by SDS-PAGE and HPLC analyses.
Storage	This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C. Avoid repeated freeze/thaw cycles.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500120-1	IX02895-1	1mg	$2621		Add to Cart
BHP18500120-2	IX02895-20	20ug	$199		Add to Cart

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