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Home / Proteins & Peptide

BCL-XL, His-tag

SKU : BHP18200370

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BPS Bioscience

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Mfr.No.	50273
Description	Human BCL-XL (GenBank Accession No. Z23115), a.a. 1-212 with C-terminal His-tag, MW = 28 kDa, expressed in an E. coli expression system. Host cell line: E. coli
Background	BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alteatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform (Bcl-xL) acts as an apoptotic inhibitor and the shorter form (Bcl-xS) acts as an apoptotic activator.
Immunogen Region	1-212
Tag	C-terminal His-tag
Formulation	45 mM Tris-HCl, pH 8.0, 124 mM NaCl, 2.4 mM KCl, 10% glycerol, 225 mM imidazole and 3 mM DTT.
Species	Human
Application	Useful for the study of apoptosis, screening inhibitors, and selectivity profiling.
Notes	Following the protocol for BPS Cat. #50223. Briefly, BCL-XL was combined with BCL-XL peptide ligand in TR-FRET assay buffer along with anti-His Tb donor and dye-labeled acceptor. Varying concentrations of ABT 199 were added and the reaction was incubated at room temperature for 2 hours followed by fluorescent intensity measurements. Avoid freeze/thaw cycles.
GenBank	Z23115
Mw(kda)	28 kDa

Synonyms	Bcl-Xlong, B cell lymphoma XL
Uniprot	Q07817

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	1. Meng Y. et al., Mol Cancer Ther. 2008 Jul;7(7):2192-202. 2. Asakura T. et al., Mol Int J Oncol. 2008 Aug;33(2):389-95.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200370	50273	100 ug	$495		Add to Cart

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