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Home / Proteins & Peptide

Bas (PTPN13), GST-tag

SKU : BHP18200036

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Mfr.No.	30024
Description	Human, recombinant PTP-Bas, catalytic domain (Gene bank accession number NM_080685), a.a. 2091-2490 (catalytic domain), with N-terminal GST tag, MW=71.8kDa, expressed in an E. coli expression system. Specific activity: 5 U/ug Unit definition: One unit will hydrolyze 1 nmol p-nitrophenyl phosphate per minute at pH 7.4 and 30°C.
Background	PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPN13 is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal-associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. PTPN13 binds to a negative regulatory domain in Fas that inhibits Fas-induced apoptosis.
Immunogen Region	2091-2490
Tag	N-terminal GST-tag
Formulation	25 mM Tris-HCl, pH 8.0, 75 mM NaCl, 0.05% Tween-20, 50% glycerol, 2 mM EDTA, 1 mM DTT, 10 mM glutathione.
Species	Human
Application	Useful for the study of enzyme kinetics and regulation, to dephosphorylate target substrates and for screening inhibitors.
Notes	The specific activity of Bas was determined using pNPP. Assay conditions: 50 mM HEPES, pH 7.4, 2 mM EDTA, 3 mM DTT, 100 mM NaCl, 20 mM pNPP, and 20 ng/ul enzyme for 5 minutes at 30°C. Avoid freeze/thaw cycles.
GenBank	NM_080685
Mw(kda)	71.8 kDa

Synonyms	Bas, FAP-1, PTPN13, APO-1/CD95-Associated Phosphatase 1, PTP-BAS, PNP1, PTP1E, PTPL1, PTPLE, PTP-BL, Fas-Associated Phosphatase 1
Uniprot	Q12923

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	>12 months at -80°C

Reference	1. W. Kimber, et al., Biochem.J. 2003, 376: 525-535. 2. N. Kachel, et al. J.Mol. Biol. 2003, 334: 143-155.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200036	30024	50 ug was 20 ug	$357.50		Add to Cart

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