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Home / Proteins & Peptide

B7-H2/ICOSLG Fc Chimera, Human

SKU : BHP18500511

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iXCells Biotechnologies

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Mfr.No.	IX03414, IX03414-1, IX03414-100
Description	B7-H2, best known as the ligand of inducible co-stimulator, belongs to B7-CD28 family. B7-H2 is a transmembrane glycoprotein of approximately 60 kDa and is expressed on antigen presenting cells such as B cells, macrophages, dendritic cells, and also in monocytes. It s a ligand for CD28 and CTLA-4 in human, whereas these interactions are not conserved in mouse. B7-H2 and B7-1 or B7-2 interacts with CD28 through distinctive domains. B7-H2-CD28 interaction is essential for the co-stimulation of human T cells' primary responses to allogeneic antigens and memory recall responses.?Recombinant Human B7-H2 Fc Chimera produced in HEK293 cells. It s a polypeptide chain containing 473 amino acids with the C-termimal human IgG1 Fc fragment. A fully biologically active molecule, rhB7-H2 has a molecular mass of 70-80 kDa, analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
Reconstitution	Reconstituted in ddH2O at 100 ug/mL.
Formulation	Lyophilized from a 0.2 um filtered solution in PBS, 5% trehalose and mannitol.
Molecular Weight	70-80 kDa, observed by reducing SDS-PAGE.
Source	HEK293
Host	Human
Accession Number	O75144
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Notes	For research use only
Bioactivity	Immobilized ICOS Fc Chimera, Human(Cat:Z03412) at 5 ug/mL (100 uL/well) can bind Biotin-B7-H2/ICOSLG Fc Chimera, Human with a linear range of 0.76-12.21ng/mL when detected by Streptavidin-HRP second antibody..

Synonyms	ICOSLG; B7-H2; B7H2; B7RP-1; B7RP1; CD275; GL50; ICOS-L; ICOSL; LICOS; ICOS ligand
Sequence	DTQEKEVR AMVGSDVE LSCACPEG SRFDLNDV YVYWQTSE?SKTVVTYH IPQNSSLE NVDSRYRN RALMSPAG MLRGDFSL?RLFNVTPQ DEQKFHCL VLSQSLGF QEVLSVEV TLHVAANF?SVPVVSAP HSPSQDEL TFTCTSIN GYPRPNVY WINKTDNS?LLDQALQN DTVFLNMR GLYDVVSV LRIARTPS VNIGCCIE?NVLLQQNL TVGSQTGN DIGERDKI TENPVSTG EKNAATWS

Purity	97% as analyzed by reducing SDS-PAGE.
Storage	Lyophilized recombinant B7-H2 Fc Chimera, Human remains stable for up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Human B7-H2 Fc should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500511-1	IX03414-1	1mg	$1498		Add to Cart
BHP18500511-2	IX03414-100	100ug	$313		Add to Cart

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