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Home / Proteins & Peptide

ALK2, GST-tag

SKU : BHP18200139

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BPS Bioscience

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Mfr.No.	40019
Description	Recombinant human activin receptor-like kinase 2, or ALK2 (a.a. 147-end), with N-terminal GST-tag, expressed by Sf9 insect cells via a baculovirus expression system. The gene accession number is NM_001105. host species: Sf9 cells Host species: Sf9 cells
Background	ALK 2 is a receptor serine/threonine kinase that is member of the ALK family and is upstream of signaling pathway involving the SMAD proteins especially SMAD1/5/8. Knockdown of ALK2, but not TGFbetaRI (ALK5), abrogates endoglin-mediated decrease in cell motility of prostate cancer cells and constitutively active ALK2 is sufficient to restore a low-motility phenotype in endoglin deficient cells (1). Therefore, endoglin decreases prostate cancer cell motility through activation of the ALK2-Smad1 pathway. ALK2 is the key gene involved in Fibrodysplasia ossificans progressiva (FOP), a rare autosomal dominant congenital disorder characterized by progressive heterotopic bone formation in muscle tissues (2).
Immunogen Region	147-end
Tag	N-terminal GST-tag
Formulation	50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.
Species	Human
Application	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Notes	Avoid freeze/thaw cycles.
GenBank	NM_001105
Mw(kda)	67 kDa

Synonyms	ActRIA, ACVR1, ACTRI, ACVR1A, ACVRLK2, FOP, SKR1, TSRI, Haspin-like
Uniprot	Q04771

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Purity	>=75%
Storage	At least 6 months at -80°C.

Reference	1. Craft, C.S. et al . Oncogene. 2007 Nov 8;26(51):7240-50. 2. Shore, E. M. et al . Nature Genet. 38: 525-527, 2006.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200139	40019	10 ug	$429		Add to Cart

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