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Home / Proteins & Peptide

Active Human Recombinant Truncated Tau (AA297-391) (dGAE C322A) Protein Pre-formed Fibrils BHP11901172

SKU : BHP11901172

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StressMarq Biosciences Inc.

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Mfr.No.	SPR-462, SPR-462B, SPR-462C, SPR-462E
Description	Active Human Recombinant Truncated Tau (AA297-391) (dGAE C322A) Protein Pre-formed Fibrils
Alternative Names	Active tau aggregate, tau PFFs, tau PFF, active tau protein aggregate, active tau protein, microtubule-associated protein tau, MAPT, MAP, microtubule-associated protein, Truncated Tau Protein Aggregate, Paired Helical Filament-Tau, Phf-Tau, Neurofibrillary Tangle Protein, G Protein Beta1/Gamma2 Subunit-Interacting Factor 1, Isoform 2, tubulin-associated unit, 95-amino acid tau protein fragment, Truncated Tau Protein
Cellular Localization	Cell membrane, Cytoskeleton, Growth cone, Peripheral membrane protein, Cytoplasm, Axolemma, Axolemma Plasma Membrane, Axon, Cell Body, Cytoplasmic Ribonucleoprotein Granule, Cytoplasmic Side, Cytosol, Dendrite, Microtubule, Microtubule Associated Complex, Neurofibrillary Tangle, Neuronal Cell Body, Nuclear Periphery, Nuclear Speck, Nucleus, Plasma Membrane, Tubulin Complex
Certificate Of Analysis	Certified >95% pure using SDS-PAGE analysis.
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.
Scientific Background	Alzheimer s Disease (AD) is the most common neurodegenerative disease, affecting 10% of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing paired helical filaments (PHFs). A truncated 95-amino acid fragment corresponding to residues 297-391 of full-length tau has been shown to assemble into PHF-like fibrils in vitro in the absence of additives or templates (3). This fragment has been found in the core of PHFs from AD brains and forms filaments that closely resemble PHFs isolated from AD brains (3). The C322A mutation leads to enhanced self-assembly into long and ordered PHFs (3).
Species	Human
Accession Number	NP_005901.2
Concentration	Lot/batch specific. See included datasheet.
Purification	Ion-exchange Purified
Expression System	E. coli
Bioactivity	Thioflavin T emission curves show increased fluorescence (correlated to tau aggregation) over time when truncated tau fragment (AA297-391) (dGAE C322A) monomer is combined with truncated tau fragment (AA297-391) (dGAE C322A) Pre-formed Fibrils.
Biological Activity Abreviation	Active
Cite This Product	Human Recombinant Tau Protein (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SPR-462E)
Mol Weight	10.133 kDa
Nature	Recombinant
Other Relevant Information	For best results, sonicate immediately prior to use. Refer to the Neurodegenerative Protein Handling Instructions on our website, or on the product datasheet for further information..
Protein Length	Fragment

Gross Weight (kg)	1.4
Launch Date	03-18-2019
Net Weight (g)	0.5
Swissprot	P10636
Gene Id	4137
Research Area	Tangles & Tau, Alzheimer's Disease, Axon Markers, Cell Markers, Cell Signaling, Microtubules, MT Associated Proteins, Neurodegeneration, Neuron Markers, Neuroscience, Cytoskeleton
Target	Tau

Country Of Origin	Canada
Stock Product	Y
Tarriff Code	3822.00.1090
Shipping Temperature	Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.
Purity	>95%
Storage Buffer	PBS pH 7.4
Storage Temperature	-80°C

Applications	In vivo assay, In vitro assay, WB, SDS-PAGE

Reference	1. Arlander SJH, et al. (2003) J Biol Chem 278: 52572-52577. 2. Pearl H, et al. (2001) Adv Protein Chem 59:157-186. 3. Neckers L, et al. (2002) Trends Mol Med 8:S55-S61. 4. Pratt W, Toft D. (2003) Exp Biol Med 228:111-133. 5. Pratt W, Toft D. (1997) Endocr Rev 18: 306- 360. 6. Pratt WB. (1998) Proc Soc Exptl Biol Med 217: 420- 434. 7. Whitesell L, et al. (1994) Proc Natl Acad Sci USA 91: 8324- 8328. 8. Perdew, G. H. (1988) JBC 263 (27): 13802-13805 9. Dalman, F. C. et al.(1989) JBC 264(33): 19815-19821 10. Uma, S. et al. (1997) JBC 272(17): 11648-11656.

Product Manual	Datasheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP11901172-1	SPR-462B	100 ug	$432		Add to Cart
BHP11901172-2	SPR-462C	2X100 ug	$691		Add to Cart
BHP11901172-3	SPR-462E	5X100 ug	$1405		Add to Cart

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