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Home / Proteins & Peptide

Active Human Recombinant Tau441 (2N4R) P301S Mutant Protein Pre-formed Fibrils BHP11901193

SKU : BHP11901193

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StressMarq Biosciences Inc.

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Mfr.No.	SPR-471, SPR-471B, SPR-471C, SPR-471E
Description	Active Human Recombinant Tau441 (2N4R) P301S Mutant Protein Pre-formed Fibrils
Alternative Names	Active tau PFFs, tau PFF, active tau protein Pre-formed Fibrils, active tau aggregates, microtubule-associated protein tau, MAPT, MAP, microtubule-associated protein, Paired Helical Filament-Tau, Phf-Tau, Neurofibrillary Tangle Protein, G Protein Beta1/Gamma2 Subunit-Interacting Factor 1, Isoform 4, tubulin-associated unit, mouse tau protein, P301S mutant tau, 2N4R tau, Tau441
Cellular Localization	Cell membrane, Cytoskeleton, Growth cone, Peripheral membrane protein, Cytoplasm, Axolemma, Axolemma Plasma Membrane, Axon, Cell Body, Cytoplasmic Ribonucleoprotein Granule, Cytoplasmic Side, Cytosol, Dendrite, Microtubule, Microtubule Associated Complex, Neurofibrillary Tangle, Neuronal Cell Body, Nuclear Periphery, Nuclear Speck, Nucleus, Plasma Membrane, Tubulin Complex
Certificate Of Analysis	Certified >95% pure using SDS-PAGE analysis.
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.
Scientific Background	Alzheimer s Disease (AD) is the most common neurodegenerative disease, affecting 10% of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing hyperphosphorylated tau fibrils (3). There are six isoforms of tau in the adult human brain: three with four repeat units (4R) and three with three repeat units (3R) (4). 2N4R, or Tau-441 is the full length tau protein. P301S is a mutation encoded by exon 10 (4) that impairs the ability of tau to assemble microtubules (5).
Species	Human
Accession Number	NP_005901.2
Concentration	Lot/batch specific. See included datasheet.
Purification	Ion-exchange Purified
Expression System	Baculovirus
Bioactivity	Thioflavin T emission curves show increased fluorescence (correlated to tau aggregation) over time when tau monomers (SPR-473) are combined with tau fibrils (SPR-471).
Biological Activity Abreviation	Active
Cite This Product	Human Recombinant Tau Protein (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SPR-471E)
Mol Weight	~45.8 kDa
Nature	Recombinant
Other Relevant Information	Endotoxin <0.05 EU/mL (below the detectable range of the assay). SPR-471 is post-translationally modified due to baculovirus/SF9 insect cells expression system.
Protein Length	Full Length

Gross Weight (kg)	1.4
Launch Date	04-04-2020
Net Weight (g)	0.05
Swissprot	P10636
Gene Id	4137
Research Area	Tangles & Tau, Alzheimer's Disease, Axon Markers, Cell Markers, Cell Signaling, Microtubules, MT Associated Proteins, Neurodegeneration, Neuron Markers, Neuroscience, Cytoskeleton
Target	Tau

Country Of Origin	Canada
Stock Product	Y
Tarriff Code	3822.00.1090
Shipping Temperature	Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.
Purity	>95%
Storage Buffer	PBS pH 7.4
Storage Temperature	-80°C

Applications	In vivo assay, In vitro assay, WB, SDS-PAGE

Reference	1. Arlander SJH, et al. (2003) J Biol Chem 278: 52572-52577. 2. Pearl H, et al. (2001) Adv Protein Chem 59:157-186. 3. Neckers L, et al. (2002) Trends Mol Med 8:S55-S61. 4. Pratt W, Toft D. (2003) Exp Biol Med 228:111-133. 5. Pratt W, Toft D. (1997) Endocr Rev 18: 306- 360. 6. Pratt WB. (1998) Proc Soc Exptl Biol Med 217: 420- 434. 7. Whitesell L, et al. (1994) Proc Natl Acad Sci USA 91: 8324- 8328. 8. Perdew, G. H. (1988) JBC 263 (27): 13802-13805 9. Dalman, F. C. et al.(1989) JBC 264(33): 19815-19821 10. Uma, S. et al. (1997) JBC 272(17): 11648-11656.

Product Manual	Datasheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP11901193-1	SPR-471B	100 ug	$545		Add to Cart
BHP11901193-2	SPR-471C	2X100 ug	$871		Add to Cart
BHP11901193-3	SPR-471E	5X100 ug	$1769		Add to Cart

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