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Home / Proteins & Peptide

Active Human Recombinant Tau (K18) Delta K280 Mutant Protein Pre-formed Fibrils BHP11901208

SKU : BHP11901208

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StressMarq Biosciences Inc.

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Mfr.No.	SPR-477, SPR-477B, SPR-477C, SPR-477E
Description	Active Human Recombinant Tau (K18) Delta K280 Mutant Protein Pre-formed Fibrils
Alternative Names	Active tau PFFs, tau PFF, active tau protein Pre-formed Fibrils, active tau aggregates, microtubule-associated protein tau, MAPT, MAP, microtubule-associated protein, Paired Helical Filament-Tau, Phf-Tau, Neurofibrillary Tangle Protein, G Protein Beta1/Gamma2 Subunit-Interacting Factor 1, Isoform 4, tubulin-associated unit, MAPT DeltaK280, deltaK280 tau, K18 delta K280 tau, truncated deltaK280 tau
Cellular Localization	Cell membrane, Cytoskeleton, Growth cone, Peripheral membrane protein, Cytoplasm, Axolemma, Axolemma Plasma Membrane, Axon, Cell Body, Cytoplasmic Ribonucleoprotein Granule, Cytoplasmic Side, Cytosol, Dendrite, Microtubule, Microtubule Associated Complex, Neurofibrillary Tangle, Neuronal Cell Body, Nuclear Periphery, Nuclear Speck, Nucleus, Plasma Membrane, Tubulin Complex
Certificate Of Analysis	Certified >95% pure using SDS-PAGE analysis.
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.
Scientific Background	Alzheimer s Disease (AD) is the most common neurodegenerative disease, affecting 10% of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing hyperphosphorylated tau fibrils (3). The deltaK280 mutation is associated with frontotemporal dementia and promotes fibrillization into paired helical filaments (PHFs) in the absence of heparin and other inducers (4). K18 is a truncated form of human tau containing only the 4 microtubule binding repeats (5).
Species	Human
Concentration	Lot/batch specific. See included datasheet.
Purification	Ion-exchange Purified
Expression System	E. coli
Biological Activity Abreviation	Under Investigation
Cite This Product	Human Recombinant Tau Protein (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SPR-477E)
Mol Weight	~15 kDa
Nature	Recombinant
Protein Length	Partial

Gross Weight (kg)	1.4
Launch Date	08-28-2019
Net Weight (g)	0.5
Swissprot	P10636
Gene Id	4137
Research Area	Tangles & Tau, Alzheimer's Disease, Axon Markers, Cell Markers, Cell Signaling, Microtubules, MT Associated Proteins, Neurodegeneration, Neuron Markers, Neuroscience, Cytoskeleton
Target	Tau

Country Of Origin	Canada
Stock Product	Y
Tarriff Code	3822.00.1090
Shipping Temperature	Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.
Purity	>95%
Storage Buffer	PBS pH 7.4
Storage Temperature	-80°C

Applications	In vivo assay, In vitro assay, WB, SDS-PAGE

Reference	1. Hartl, F.U. (1996) Nature 381: 571-579. 2. Bukau, B. and Horwich, A.L. (1998) Cell 92: 351-366. 3. Hartl, F.U. and Hayer-Hartl, M. (2002) Science 295: 1852- 1858. 4. Jindal, S., et al. (1989) Molecular and Cellular Biology 9: 2279-2283. 5. La Verda, D., et al (1999) Infect Dis. Obstet. Gynecol. 7: 64-71. 6. Itoh, H. et al. (2002) Eur. J. Biochem. 269: 5931-5938. 7. Gupta, S. and Knowlton, A.A. J. Cell Mol Med. 9: 51-58. 8. Deocaris, C.C. et al. (2006) Cell Stress Chaperones 11: 116-128. 9. Lai, H.C. et al. (2007) Am. J. Physiol. Endocrinol. Metab. 292: E292-E297. 10. Gao, Y.L., et al (1995) J. of Immunology 154: 3548-3556. 11. Neuer, A., et al (1997) European Society for Human Reproduction and Embryology 12(5):925-929. 12. Bason, C., et al (2003) Lancet 362(9400): 1971-1977.

Product Manual	Datasheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP11901208-1	SPR-477B	100 ug	$382		Add to Cart
BHP11901208-2	SPR-477C	2X100 ug	$611		Add to Cart
BHP11901208-3	SPR-477E	5X100 ug	$1240		Add to Cart

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