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Home / Proteins & Peptide

Active Human Recombinant N-Terminal Acetylated Alpha Synuclein Pre-formed Fibrils (Type 1) BHP11901124

SKU : BHP11901124

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StressMarq Biosciences Inc.

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Mfr.No.	SPR-332, SPR-332B, SPR-332C, SPR-332E
Description	Active Human Recombinant N-Terminal Acetylated Alpha Synuclein Pre-formed Fibrils (Type 1)
Alternative Names	Active tau PFFs, tau PFF, active tau protein Pre-formed Fibrils, active tau aggregates, microtubule-associated protein tau, MAPT, MAP, microtubule-associated protein, Paired Helical Filament-Tau, Phf-Tau, Neurofibrillary Tangle Protein, G Protein Beta1/Gamma2 Subunit-Interacting Factor 1, Isoform 4, tubulin-associated unit, mouse tau protein, P301S mutant tau, 2N4R tau, Tau441, fluorescent tau fibrils, ATTO 488 conjugated tau
Cellular Localization	Cytoplasm, Membrane, Nucleus
Certificate Of Analysis	Acetylation cofirmed via ESI mass spectrometry
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.
Scientific Background	Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6). Alpha synuclein purified from both normal and pathological brain tissue is N-acetylated (7) and this post-translational modification affects affect alpha-synuclein stability and toxicity (8).
Species	Human
Accession Number	NP_000336.1
Concentration	Lot/batch specific. See included datasheet.
Purification	Ion-exchange Purified
Expression System	E. coli
Bioactivity	Seeds aggregation of N-acetylated alpha synuclein monomer (SPR-331) in thioflavin T assay
Biological Activity Abreviation	Active
Cite This Product	Human Recombinant Alpha Synuclein Protein (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SPR-332E)
Mol Weight	~14.46kDa
Nature	Recombinant
Protein Length	Full Length

Gross Weight (kg)	1.4
Launch Date	02-08-2021
Net Weight (g)	0.05
Swissprot	P37840
Gene Id	6622
Research Area	Tangles & Tau, Neurodegeneration, Alzheimer's Disease, Parkinson's Disease, Synuclein, Neuroscience
Target	Alpha Synuclein

Country Of Origin	Canada
Stock Product	Y
Tarriff Code	3822.00.1090
Shipping Temperature	Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.
Purity	>95%
Storage Buffer	PBS pH 7.4
Storage Temperature	-80°C

Applications	In vivo assay, In vitro assay, WB, SDS-PAGE

Reference	1. Nemoto T., et al. (1997) J.Biol Chem. 272: 26179-26187. 2. Minami Y., et al. (1991), J.Biol Chem. 266: 10099-10103. 3. Arlander S.J.H., et al. (2003) J Biol Chem 278: 52572-52577. 4. Pearl H., et al. (2001) Adv Protein Chem 59:157-186. 5. Neckers L., et al. (2002) Trends Mol Med 8:S55-S61. 6. Pratt W., Toft D. (2003) Exp Biol Med 228:111-133. 7. Pratt W., Toft D. (1997) Endocr Rev 18:306- 360. 8. Pratt W.B. (1998) Proc Soc Exptl Biol Med 217: 420- 434. 9. Whitesell L., et al. (1994) Proc Natl Acad Sci USA 91: 8324- 8328. 10. Barent R. L. (1998) Mol. Endocrinol. 12: 342-354 11. Lo. M.A. (1998) EMBO J. 17: 6879-6887.

Product Manual	Datasheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP11901124-1	SPR-332B	100 ug	$418		Add to Cart
BHP11901124-2	SPR-332C	2X100 ug	$669		Add to Cart
BHP11901124-3	SPR-332E	5X100 ug	$1359		Add to Cart

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