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Active Human Recombinant Alpha Synuclein Protein Filaments BHP11901151

SKU : BHP11901151

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StressMarq Biosciences Inc.

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Mfr.No.	SPR-450, SPR-450B, SPR-450C, SPR-450E
Description	Active Human Recombinant Alpha Synuclein Protein Filaments
Alternative Names	Alpha synuclein Filament, Alpha synuclein aggregates, Alpha synuclein PFF, Alpha synuclein PFFs, Alpha synuclein protein aggregates, Active Alpha synuclein aggregates, Alpha-synuclein protein, Non-A beta component of AD amyloid protein, Non-A4 component of amyloid precursor protein, NACP protein, SNCA protein, NACP protein, PARK1 protein, SYN protein, Parkinson's disease familial 1 Protein, alpha synuclein protofibrils, alpha synuclein proto-fibrils
Cellular Localization	Cytoplasm, Membrane, Nucleus
Certificate Of Analysis	Certified >95% pure using SDS-PAGE analysis.
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.
Scientific Background	Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6).
Species	Human
Accession Number	NP_000336.1
Concentration	Lot/batch specific. See included datasheet.
Purification	Ion-exchange Purified
Expression System	E. coli
Biological Activity Abreviation	Active
Cite This Product	Human Recombinant Alpha Synuclein Protein (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SPR-450E)
Mol Weight	~14.46kDa
Nature	Recombinant
Other Relevant Information	For best results, sonicate immediately prior to use. Refer to the Neurodegenerative Protein Handling Instructions on our website, or on the product datasheet for further information..
Protein Length	Full length

Gross Weight (kg)	1.4
Launch Date	03-18-2019
Net Weight (g)	0.5
Swissprot	P37840
Gene Id	6622
Research Area	Tangles & Tau, Neurodegeneration, Alzheimer's Disease, Parkinson's Disease, Synuclein, Neuroscience
Target	Alpha Synuclein

Country Of Origin	Canada
Stock Product	Y
Tarriff Code	3822.00.1090
Shipping Temperature	Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.
Purity	>95%
Storage Buffer	PBS pH 7.4
Storage Temperature	-80°C

Applications	In vivo assay, In vitro assay, WB, SDS-PAGE

Reference	1. Nemoto, T. et al. (1997) J.Biol Chem. 272: 26179-26187. 2. Minami, Y, et al. (1991), J.Biol Chem. 266: 10099-10103. 3. Arlander SJH, et al. (2003) J Biol Chem. 278: 52572-52577. 4. Pearl H, et al. (2001) Adv Protein Chem. 59: 157-186. 5. Neckers L, et al. (2002) Trends Mol Med. 8: S55-S61. 6. Pratt W, Toft D. (2003) Exp Biol Med. 228: 111-133. 7. Pratt W, Toft D. (1997) Endocr Rev. 18: 306- 360. 8. Pratt WB. (1998) Proc Soc Exptl Biol Med. 217: 420- 434. 9. Whitesell L, et al. (1994) Proc Natl Acad Sci USA. 91: 8324- 8328. 10. Nemoto, T. (1997) Biochem and Mol. Bio Intl. 42 (5): 881-889.

Product Manual	Datasheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP11901151-1	SPR-450B	100 ug	$382		Add to Cart
BHP11901151-2	SPR-450C	2X100 ug	$611		Add to Cart
BHP11901151-3	SPR-450E	5X100 ug	$1240		Add to Cart

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