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Home / Proteins & Peptide

4-1BB R/TNFRSF9, Human

SKU : BHP18500152

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iXCells Biotechnologies

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Mfr.No.	IX02933, IX02933-1, IX02933-20, IX02933-5
Description	4-1BB Receptor, also named TNFRSF9 is a member of the TNF superfamily of receptors. It is mainly expressed on the surface of a variety of T cells, but also found in B cells, monocytes, and various transformed cell lines. 4-1BB Receptor binds to 4-1BBL to provide a co-stimulatory signal for T lymphocytes. Signaling by 4-1BB Receptor has been implicated in the antigen-presentation process and generation of cytotoxic T cells.
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <= -20 °C. Further dilutions should be made in appropriate buffered solutions.
Formulation	Lyophilized from a 0.2 um filtered concentrated solution in 10 mM PB, pH 8.0, 150 mM NaCl.
Molecular Weight	Approximately 17.7 kDa, a single non-glycosylated polypeptide chain containing 166 amino acids.
Physical Appearance	Sterile Filtered White lyophilized (freeze-dried) powder.
Source	E. coli
Host	Human
Endotoxin Level	Less than 1 EU/ug of rHu4-1BB Receptor as determined by LAL method.
Bioactivity	Fully biologically active when compared to standard. The biological activity is determined by its inhibitory effect of IL-8 production using human peripheral blood mononuclear cells. About 90 % of inibition was seen using a concentration of 1 ug for both 4-1BB Ligand and 4-1BB Receptor.

Synonyms	TNFRSF9, CD137 antigen, T-cell antigen ILA
Sequence	ERTRSLQDPC SNCPAGTFCD NNRNQICSPC PPNSFSSAGGQRTCDICRQC KGVFRTRKEC?SSTSNAECDC TPGFHCLGAG CSMCEQDCKQGQELTKKGCK DCCFGTFNDQ?KRGICRPWTN CSLDGKSVLV NGTKERDVVCGPSPADLSPG ASSVTPPAPA REPGHS

Purity	97 % by SDS-PAGE and HPLC analyses.
Storage	This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C. Avoid repeated freeze/thaw cycles.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500152-1	IX02933-1	1mg	$2621		Add to Cart
BHP18500152-2	IX02933-20	20ug	$199		Add to Cart
BHP18500152-3	IX02933-5	5ug	$82		Add to Cart

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