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Home / Primary Antibodies / Polyclonal Antibodies

YTHDC1 antibody

SKU : BHA10809542

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Mfr.No.	FNab09571
Alternative Names	KIAA1966 ; PutativesplicingfactorYT521 ; YT521 ; YT521B ; YTHdomaincontaining1 ; YTHDC1
Background	Regulator of alteative splicing that specifically recognizes and binds N6-methyladenosine(m6A)-containing RNAs(PubMed:26318451, PubMed:26876937, PubMed:25242552). M6A is a modification present at inteal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability(PubMed:26318451, PubMed:25242552). Acts as a key regulator of exon-inclusion or exon-skipping during alteative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10(PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alteative splicing(PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alteative splicing(PubMed:26876937). May also regulate alteative splice site selection(PubMed:20167602).
Categories	Primary Antibodies
Clonality	polyclonal
Description	Regulator of alteative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:26318451, PubMed:26876937, PubMed:25242552). M6A is a modification present at inteal sites of mRNAs and some non- coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:26318451, PubMed:25242552). Acts as a key regulator of exon-inclusion or exon-skipping during alteative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A- containing mRNAs and promotes recruitment of SRSF3 to its mRNA- binding elements adjacent to m6A sites, leading to exon-inclusion during alteative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alteative splicing (PubMed:26876937). May also regulate alteative splice site selection (PubMed:20167602).
Host	Rabbit
Immunogen	YTH domain containing 1
Isotype	IgG
Molecular Weight	110 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	KIAA1966, Putative splicing factor YT521, YT521, YT521 B, YTH domain containing 1, YTHDC1

Uniprot	Q96MU7
Gene Id	91746
Research Area	Metabolism
Weight	85kDa,Observed 110kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB

Description

ELISA ; WB

Dilution

WB	1:200-1:1000

Tested Application

WB: 1:200-1:1000

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809542	FNab09571	100ug	$300		Add to Cart

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