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Home / Primary Antibodies / Polyclonal Antibodies

XRCC2 antibody

SKU : BHA10809524

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Mfr.No.	FNab09553
Alternative Names	DKFZp781P0919 ; DNArepairproteinXRCC2 ; XRCC2
Background	This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents.
Categories	Primary Antibodies
Cellular Localization	Cytoplasm, cytoskeleton, Nucleus
Clonality	polyclonal
Description	Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2- dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.
Host	Rabbit
Immunogen	X-ray repair complementing defective repair in Chinese hamster cells 2
Isotype	IgG
Molecular Weight	32 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Cytoplasm, Cytoskeleton, Nucleus
Synonyms	DKFZp781P0919, DNA repair protein XRCC2, XRCC2

Uniprot	O43543
Gene Id	7516
Research Area	Epigenetics, Developmental biology, Metabolism
Weight	32kDa,Observed 40kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB

Description

ELISA ; WB

Dilution

WB	1:200-1:2000
IP	1:200-1:2000

Tested Application

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200

Manual	FNab09553.pdf

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809524	FNab09553	100ug	$300		Add to Cart

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