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Home / Primary Antibodies / Promotion

WIPI2 antibody

SKU : BHA10809487

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Mfr.No.	FNab09513
Alternative Names	WIPI2 ; FLJ14217 ; WIPI2 ; WIPI49likeprotein2 ; FLJ42984
Background	WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 (PubMed 15602573)).
Categories	Primary Antibodies
Clonality	polyclonal
Description	Early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to phosphatidylinositol 3-phosphate (PtdIns3P). May bind PtdIns3P. Isoform 4: Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes and preautophagosomal structures, resulting in ATG8 family proteins lipidation and starvation-induced autophagy. Isoform 4 is also required for autophagic clearance of pathogenic bacteria. Isoform 4 binds the membrane surrounding Salmonella and recruits the ATG12-5-16L1 complex, initiating LC3 conjugation, autophagosomal membrane formation, and engulfment of Salmonella.
Host	Rabbit
Immunogen	WD repeat domain, phosphoinositide interacting 2
Isotype	IgG
Molecular Weight	48 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	WIPI2, FLJ14217, WIPI 2, WIPI49 like protein 2, FLJ42984

Uniprot	Q9Y4P8
Gene Id	26100
Research Area	Metabolism
Weight	49kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB

Description

ELISA ; WB

Dilution

WB	1:200-1:2000

Tested Application

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab09513.pdf

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809487	FNab09513	100ug	$300		Add to Cart

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