This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alteatively spliced transcript variants encoding different isoforms have been described for this gene.
Clonality
polyclonal
Host
Rabbit
Immunogen
Guanine nucleotide exchange factor VAV3
Immunogen Region
Guanine nucleotide eXchange factor VAV3
Isotype
IgG
Molecular Weight
90-100 kDa
Reactivity
Human, Mouse, Rat
Recommended Dilution
WB: 1:500-1:2000
Subcellular Location
Cell membrane, Membrane
Synonyms
VAV-3
Uniprot
Q9UKW4
Gene Id
10451
Research Area
Developmental biology, Cell Division and Proliferation, Stem Cells, Metabolism
Form
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Tested Application
WB: 1:500-1:2000
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10378.pdf" target="_blank">Data Sheet</ a>