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Home / Primary Antibodies / Polyclonal Antibodies

UBE2S antibody

SKU : BHA10809175

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Mfr.No.	FNab09183
Alternative Names	E2EPF ; E2EPF ; EPF5 ; UBE2S ; UbiquitincarrierproteinS ; UbiquitinproteinligaseS
Background	This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of ubiquitin carrier proteins.
Categories	Primary Antibodies
Cellular Localization	Cytoplasm
Clonality	polyclonal
Description	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as a E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination.
Host	Rabbit
Immunogen	ubiquitin-conjugating enzyme E2S
Isotype	IgG
Molecular Weight	25 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	cytoplasm
Synonyms	E2 EPF, E2EPF, EPF5, UBE2S, Ubiquitin carrier protein S, Ubiquitin protein ligase S

Uniprot	Q16763
Gene Id	27338
Research Area	Epigenetics, Metabolism
Weight	24kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC, FC, IP

Description

ELISA ; WB ; IHC ; FC ; IP

Dilution

WB	1:200-1:2000
IP	1:500-1:5000
IHC	1:20-1:200

Tested Application

WB: 1:200 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab09183.pdf

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809175	FNab09183	100ug	$300		Add to Cart

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