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Home / Primary Antibodies / Polyclonal Antibodies

TTBK2 antibody

SKU : BHA10809068

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Mfr.No.	FNab09076
Alternative Names	KIAA0847 ; SCA11 ; tautubulinkinase2 ; TTBK ; TTBK2
Background	This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this gene cause spinocerebellar ataxia type 11 (SCA11); a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem.
Categories	Primary Antibodies
Cellular Localization	Nucleus, Ytoplasm
Clonality	polyclonal
Description	Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro.
Host	Rabbit
Immunogen	tau tubulin kinase 2
Isotype	IgG
Molecular Weight	137 kDa
Reactivity	Human, Rat
Regulatory	RUO
Subcellular Location	Nucleus,cytoplasm
Synonyms	KIAA0847, SCA11, tau tubulin kinase 2, TTBK, TTBK2

Uniprot	Q6IQ55
Gene Id	146057
Research Area	Cell Division and Proliferation, Metabolism, Neuroscience
Weight	137kDa,Observed 150kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC

Dilution

WB	1:500-1:5000
IHC	1:20-1:200
IF	1:20-1:200

Tested Application

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab09076.pdf

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809068	FNab09076	100ug	$300		Add to Cart

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