This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis.
Categories
Primary Antibodies
Cellular Localization
Mitochondria
Clonality
polyclonal
Description
TXN2(Thioredoxin-2) is also named as TRX2,MTRX,Mt-TRX and regulates the mitochondrial redox state and plays an important role in cell proliferation.It has been shown that cells conditionally deficient in Trx2 undergo apoptosis in the absence of exogenous stress, accompanied by an accumulation of intracellular ROS, the activation of caspase 9 and caspase 3, and the release of cytochrome c into the cytosol.In the retina, the expression profile and the role of Trx2 have not yet been defined(PMID:18441302).