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Home / Primary Antibodies / Promotion

TEAD4 antibody

SKU : BHA10808576

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Mfr.No.	FNab08584
Alternative Names	RTEF1 ; TCF13L1 ; TEF3
Background	Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in tu phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition(EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons'(5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in tu phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.
Host	Rabbit
Immunogen	TEA domain family member 4
Isotype	IgG
Molecular Weight	65 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	RTEF1, TCF13L1, TEF3

Uniprot	Q15561
Gene Id	7004
Research Area	Cardiovascular, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, IP, WB
Description	ELISA ; IP ; WB
Tested Application	WB: 1:500-1:2000; IP: 1:200-1:1000

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SKU	Supplier No.	Size	Your price	Quantity
BHA10808576	FNab08584	100ug	$300		Add to Cart

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