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Home / Primary Antibodies / Promotion

TAF1C antibody

SKU : BHA10808474

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Mfr.No.	FNab08482
Background	Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Multiple alteatively spliced transcript variants encoding different isoforms have been identified.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3.
Host	Rabbit
Immunogen	TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
Isotype	IgG
Molecular Weight	110 kDa
Reactivity	Human, Mouse
Regulatory	RUO

Uniprot	Q15572
Gene Id	9013
Research Area	Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB
Description	ELISA ; WB
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab08482.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10808474	FNab08482	100ug	$300		Add to Cart

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