The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in patte formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. Alteative splicing results in multiple transcript variants.
Clonality
polyclonal
Host
Rabbit
Immunogen
suppressor of fused homolog
Immunogen Region
transducin-like enhancer of split 1
Isotype
IgG
Molecular Weight
55 kDa
Reactivity
Human, Mouse, Rat
Recommended Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Synonyms
SUFU, PRO1280, SUFUH, SUFUXL
Uniprot
Q9UMX1
Gene Id
51684
Research Area
Developmental biology, Signal Transduction, Metabolism, Cancer
Form
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Application
WB: 1:500-1:2000
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10855.pdf" target="_blank">Data Sheet</ a>