This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alteative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene.
Categories
Primary Antibodies
Clonality
polyclonal
Description
Calcium-binding protein that modulates excitation- contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels.
Host
Rabbit
Immunogen
sorcin
Isotype
IgG
Molecular Weight
22 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Uniprot
P30626
Gene Id
6717
Research Area
Cardiovascular, Signal Transduction, Neuroscience
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)