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Home / Primary Antibodies / Promotion

SMC1A antibody

SKU : BHA10808008

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Mfr.No.	FNab08016
Alternative Names	DXS423E ; KIAA0178 ; SB1.8 ; SMC1 ; SMC1L1
Background	Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Coelia de Lange syndrome. Alteative splicing results in multiple transcript variants encoding different isoforms.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.
Host	Rabbit
Immunogen	structural maintenance of chromosomes 1A
Isotype	IgG
Molecular Weight	143-150 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1

Uniprot	Q14683
Gene Id	8243
Research Area	Cell Division and Proliferation, Developmental biology, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB
Description	ELISA ; WB
Tested Application	WB: 1:500 - 1:2000

Manual	FNab08016.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10808008	FNab08016	100ug	$300		Add to Cart

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