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Home / Primary Antibodies / Promotion

SKP2 antibody

SKU : BHA10807890

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Mfr.No.	FNab07898
Alternative Names	FBXL1
Background	This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alteative splicing of this gene generates three transcript variants encoding different isoforms.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration.
Host	Rabbit
Immunogen	S-phase kinase-associated protein 2 (p45)
Isotype	IgG
Molecular Weight	48 kDa
Reactivity	Human, Mouse
Regulatory	RUO
Synonyms	FBXL1

Uniprot	Q13309
Gene Id	6502
Research Area	Epigenetics, Cancer, Cardiovascular, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, IHC, WB, IP, IF
Description	ELISA ; IHC ; WB ; IP ; IF
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab07898.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10807890	FNab07898	100ug	$300		Add to Cart

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