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Home / Primary Antibodies / Polyclonal Antibodies

SIRT3 antibody

SKU : BHA10807873

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Mfr.No.	FNab07881
Alternative Names	SIR2L3
Background	This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alteatively spliced transcript variants that encode different proteins have been described for this gene.
Categories	Primary Antibodies
Clonality	polyclonal
Description	NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5O. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.
Host	Rabbit
Immunogen	sirtuin (silent mating type information regulation 2 homolog) 3
Isotype	IgG
Molecular Weight	44 kDa, 27 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	hSIRT3, SIR2 like protein 3, SIR2L3, SIRT3

Uniprot	Q9NTG7
Gene Id	23410
Research Area	Epigenetics, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB
Description	ELISA ; WB
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:100; IF: 1:50 - 1:100

Manual	FNab07881.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10807873	FNab07881	100ug	$300		Add to Cart

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