This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer.
Categories
Primary Antibodies
Clonality
polyclonal
Description
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.
Host
Rabbit
Immunogen
secreted frizzled-related protein 2
Isotype
IgG
Molecular Weight
26 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
FRP2, SARP1
Uniprot
Q96HF1
Gene Id
6423
Research Area
Developmental biology, Stem Cells, Cardiovascular, Signal Transduction
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)