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Home / Primary Antibodies / Polyclonal Antibodies

SBDS antibody

SKU : BHA10807609

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Mfr.No.	FNab07617
Background	This gene encodes a highly conserved protein that plays an essential role in ribosome biogenesis. The encoded protein interacts with elongation factor-like GTPase 1 to disassociate eukaryotic initiation factor 6 from the late cytoplasmic pre-60S ribosomal subunit allowing assembly of the 80S subunit. Mutations within this gene are associated with the autosomal recessive disorder Shwachman-Bodian-Diamond syndrome. This gene has a closely linked pseudogene that is distally located.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP- dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.
Host	Rabbit
Immunogen	Shwachman-Bodian-Diamond syndrome
Isotype	IgG
Molecular Weight	34 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO

Uniprot	Q9Y3A5
Gene Id	51119
Research Area	Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC
Description	ELISA ; WB ; IHC
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:100; IF: 1:50 - 1:200

Manual	FNab07617.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10807609	FNab07617	100ug	$300		Add to Cart

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