Negatively regulates matrix metalloproteinase-9(MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression.
Clonality
polyclonal
Host
Rabbit
Immunogen
reversion-inducing-cysteine-rich protein with kazal motifs
Immunogen Region
reversion-inducing-cysteine-rich protein with kazal motifs
Isotype
IgG
Molecular Weight
110 kDa
Reactivity
Human
Recommended Dilution
IHC: 1:20-1:200
Synonyms
RECK, ST15, reversion-inducing cysteine-rich protein with Kazal motifs
Uniprot
O95980
Gene Id
8434
Research Area
cancer
Form
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Tested Application
IHC: 1:20-1:200
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10074.pdf" target="_blank">Data Sheet</ a>