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Home / Primary Antibodies / Polyclonal Antibodies

PTRH2 antibody

SKU : BHA10806943

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Mfr.No.	FNab06951
Alternative Names	BIT1 ; PTH2
Background	The protein encoded by this gene is a mitochondrial protein with two putative domains, an N-terminal mitochondrial localization sequence, and a UPF0099 domain. In vitro assays suggest that this protein possesses peptidyl-tRNA hydrolase activity, to release the peptidyl moiety from tRNA, thereby preventing the accumulation of dissociated peptidyl-tRNA that could reduce the efficiency of translation. This protein also plays a role regulating cell survival and death. It promotes survival as part of an integrin-signaling pathway for cells attached to the extracellular matrix (ECM), but also promotes apoptosis in cells that have lost their attachment to the ECM, a process called anoikos. After loss of cell attachment to the ECM, this protein is phosphorylated, is released from the mitochondria into the cytosol, and promotes caspase-independent apoptosis through interactions with transcriptional regulators. This gene has been implicated in the development and progression of tumors, and mutations in this gene have been associated with an infantile multisystem neurologic, endocrine, and pancreatic disease (INMEPD) characterized by intellectual disability, postnatal microcephaly, progressive cerebellar atrophy, hearing impairment, polyneuropathy, failure to thrive, and organ fibrosis with exocrine pancreas insufficiency (PMID: 25574476). Alteative splicing results in multiple transcript variants encoding different isoforms.
Categories	Primary Antibodies
Clonality	polyclonal
Description	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis. Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1.
Host	Rabbit
Immunogen	peptidyl-tRNA hydrolase 2
Isotype	IgG
Molecular Weight	20 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	BIT1, PTH2

Uniprot	Q9Y3E5
Gene Id	51651
Research Area	Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC
Description	ELISA ; WB ; IHC
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:10 - 1:100

Manual	FNab06951.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10806943	FNab06951	100ug	$300		Add to Cart

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