Type II a receptor protein tyrosine phosphatases (rPTPsigma) are cell surface receptors important for nervous system development, function, and repair.The expression of rPTPsigma has previously been reported in b-cells and other target organs for INS although the probes chosen did not permit to distinguish between the splice variants.Proteolytic processing near the transmembrane domain generates an extracellular N-terminal E-domain of 130 kDa and a C-terminal P-domain of approximately 85 kDa of rPTPsigma,and the short splice variants rPTPsigma 3 and 4 contain an E-domain of 95 kDa (PMID: 16552719). rPTPsigma expression was observed in tissue lysates of the adult mouse sensory-motor cortex and thoracic spinal cord (T8-T10) as a 75-80kDa immunoreactive band (PMID: 19780196).
Categories
Primary Antibodies
Clonality
polyclonal
Description
Interacts with LAR-interacting protein LIP.1.
Host
Rabbit
Immunogen
protein tyrosine phosphatase, receptor type, S
Isotype
IgG
Molecular Weight
75-100 kDa,220 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Uniprot
Q13332
Gene Id
5802
Research Area
Developmental biology, Signal Transduction, Metabolism, Immunology, Neuroscience
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)