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Home / Primary Antibodies / Polyclonal Antibodies

PTPN11 antibody

SKU : BHA10806924

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Mfr.No.	FNab06932
Alternative Names	PTP2C ; SHPTP2
Background	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed:26742426).
Host	Rabbit
Immunogen	protein tyrosine phosphatase, non-receptor type 11
Isotype	IgG
Molecular Weight	71KDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	PTP2C, SHPTP2

Uniprot	Q06124
Gene Id	5781
Research Area	Developmental biology, Signal Transduction, Metabolism, Cardiovascular, Immunology

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC
Description	ELISA ; WB ; IHC
Tested Application	WB: 1:500 - 1:1000; IHC: 1:50 - 1:100

Manual	FNab06932.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10806924	FNab06932	100ug	$300		Add to Cart

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