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Home / Primary Antibodies / Polyclonal Antibodies

PTGDS antibody

SKU : BHA10806906

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Mfr.No.	FNab06914
Alternative Names	PDS
Background	The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.
Host	Rabbit
Immunogen	prostaglandin D2 synthase 21kDa (brain)
Isotype	IgG
Molecular Weight	21-28 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	PDS

Uniprot	P41222
Gene Id	5730
Research Area	Developmental biology, Signal Transduction, Metabolism, Cancer, Neuroscience

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC
Description	ELISA ; WB ; IHC
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab06914.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10806906	FNab06914	100ug	$300		Add to Cart

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