Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors.
Clonality
polyclonal
Host
Rabbit
Immunogen
PRKCQ
Immunogen Region
PRKCQ
Isotype
IgG
Molecular Weight
85 kDa
Reactivity
Human
Recommended Dilution
IHC: 1:50 - 1:200
Synonyms
PRKCQ, PRKCT, nPKC-theta, protein kinase C theta
Uniprot
Q04759
Gene Id
5588
Research Area
cancer, Cell Division and Proliferation, Signal Transduction, Metabolism, Immunology
Form
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Tested Application
IHC: 1:50 - 1:200
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10092.pdf" target="_blank">Data Sheet</ a>