Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
Clonality
polyclonal
Host
Rabbit
Immunogen
myeloid leukemia factor 1
Immunogen Region
myeloid leukemia factor 1
Isotype
IgG
Molecular Weight
38 kDa
Reactivity
Human, Mouse, Rat
Recommended Dilution
WB: 1:500-1:2000
Uniprot
P58340
Form
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Tested Application
WB: 1:500-1:2000
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10756.pdf" target="_blank">Data Sheet</ a>