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Home / Primary Antibodies / Polyclonal Antibodies

METTL3 antibody

SKU : BHA10805131

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Mfr.No.	FNab05139
Alternative Names	MTA70
Background	This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of inteal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine.
Categories	Primary Antibodies
Clonality	polyclonal
Description	The METTL3-METTL14 heterodimer forms a N6- methyltransferase complex that methylates adenosine residues of some RNAs and regulates the circadian clock, differentiation of embryonic stem cells and primary miRNA processing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:27281194, PubMed:9409616). In the heterodimer formed with METTL14, METTL3 probably constitutes the catalytic core (PubMed:27281194). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in the efficiency of mRNA splicing, processing, translation efficiency, editing and mRNA stability (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:9409616). M6A regulates the length of the circadian clock: acts as a early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop (By similarity). M6A also acts as a regulator of mRNA stability: in embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs (By similarity). M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) (PubMed:25799998). METTL3 also mediates methylation of pri-miRNAs, marking them for recognition and processing by DGCR8 (PubMed:25799998). Acts as a positive regulator of mRNA translation independently of the methyltransferase activity: promotes translation by interacting with the translation initiation machinery in the cytoplasm (PubMed:27117702). Its overexpression in a number of cancer cells suggests that it may participate to cancer cell proliferation by promoting mRNA translation (PubMed:27117702).
Host	Rabbit
Immunogen	methyltransferase like 3
Isotype	IgG
Molecular Weight	80 kDa
Reactivity	Human, Mouse
Regulatory	RUO
Synonyms	IME4, M6A, methyltransferase like 3, METTL3, MT A70, MTA70, Spo8

Uniprot	Q86U44
Gene Id	56339
Research Area	Metabolism, Neuroscience

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IP
Description	ELISA ; WB ; IP
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:100; IP : 1:20 - 1:50

Manual	FNab05139.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10805131	FNab05139	100ug	$300		Add to Cart

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