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Home / Primary Antibodies / Polyclonal Antibodies

MAX antibody

SKU : BHA10805025

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Mfr.No.	FNab05033
Alternative Names	BHLHD4
Background	The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alteative splicing results in multiple transcript variants.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity.
Host	Rabbit
Immunogen	MYC associated factor X
Isotype	IgG
Molecular Weight	18 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	BHLHD4

Uniprot	P61244
Gene Id	4149
Research Area	Epigenetics, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IF, IP
Description	ELISA ; WB ; IF ; IP
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200

Manual	FNab05033.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10805025	FNab05033	100ug	$300		Add to Cart

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