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Home / Primary Antibodies / Promotion

MAGED1 antibody

SKU : BHA10804938

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Mfr.No.	FNab04946
Alternative Names	NRAGE
Background	This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed.
Host	Rabbit
Immunogen	melanoma antigen family D, 1
Isotype	IgG
Molecular Weight	86KD
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	NRAGE

Uniprot	Q9Y5V3
Gene Id	9500
Research Area	Cancer

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC
Description	ELISA ; WB ; IHC
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab04946.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10804938	FNab04946	100ug	$300		Add to Cart

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