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Home / Primary Antibodies / Polyclonal Antibodies

MAD2L2 antibody

SKU : BHA10804918

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Mfr.No.	FNab04926
Alternative Names	MAD2B ; REV7
Background	The protein encoded by this gene is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. The encoded protein, which is similar to MAD2L1, is capable of interacting with ADAM9, ADAM15, REV1, and REV3 proteins.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation.
Host	Rabbit
Immunogen	MAD2 mitotic arrest deficient-like 2 (yeast)
Isotype	IgG
Molecular Weight	24 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	MAD2B, REV7

Uniprot	Q9UI95
Gene Id	10459
Research Area	Cell Division and Proliferation

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IP
Description	ELISA ; WB ; IP
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab04926.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10804918	FNab04926	100ug	$300		Add to Cart

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