This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.
Clonality
polyclonal
Host
Rabbit
Immunogen
Lysyl oxidase homolog 2
Immunogen Region
Lysyl oXidase homolog 2
Isotype
IgG
Molecular Weight
87-100 kDa
Reactivity
Human, Mouse, Rat
Recommended Dilution
WB: 1:500-1:2000
Synonyms
LOXL2, LOR, LOR2, WS9-14
Uniprot
Q9Y4K0
Form
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Tested Application
WB: 1:500-1:2000; IHC: 1:50-1:200
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10512.pdf" target="_blank">Data Sheet</ a>